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Therefore, although the VO2/DO2 ratio is increasing, but it does not cause and mean cellular hypoxia, hence aerobic metabolism is not disturbed.
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Neither cellular hypoxia nor bioenergetics failure has been seen in a septic heart [65].
Nevertheless, there was no assessment of cellular hypoxia or damage to confirm the suggestion above.
Alterations in oxygen transport pathways can result in cellular hypoxia and/or dysoxia [33].
Therefore, hyperlactatemia does not necessarily reflect anaerobic metabolism secondary to cellular hypoxia.
Metformin may also decrease cellular hypoxia of less perfused tissues by decreasing oxygen consumption.
However, alterations of tissue perfusion, source of cellular hypoxia, can coexist with optimal macrocirculatory parameters.
Shock is a state of acute circulatory failure, with inadequate tissue perfusion causing cellular hypoxia.
Thus, Ru-BrPy is a promising candidate as a molecular probe for detecting cellular hypoxia.
In case of cellular hypoxia and reoxygenation, the activation of heme oxygenase by statins could represent a protective mechanism against oxidative stress-related cellular damage [28 31].
Cellular hypoxia, in turn, can cause an increase in the flow of calcium from the extracellular fluid to the intracellular space, resulting in calcium overload and cellular dysfunction.
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CEO of Professional Science Editing for Scientists @ prosciediting.com