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Although cytotoxicity and pharmacokinetic interactions explain partially why PgP inhibitors have not been very effective in clinical trials, a clear explanation for the minimal effects to increase mean cellular accumulation of drug has yet to be provided.
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As shown in Fig. 1e, the cellular accumulation of GNP-RGD was compared with the cellular accumulation of unmodified GNPs.
Effects of LY294002 on cellular accumulation of topotecan were then evaluated by flow cytometric analysis.
e Cellular accumulation of GNPs and GNP-RGDs in MDA-MB-231 cells.
a Comparison of the cellular accumulation of GNP-RGD compared to GNP-RGD-BLMs.
The cellular accumulation of 99mTc MIBI is shown in Figure 4.
There was a six- to sevenfold increase in cellular accumulation for the GNP-RGDs.
The established cellular accumulation of cisplatin indicated uptake of the nanoconjugates by the cells through endocytosis.
Encapsulation of drugs in micelles does not change their intracellular distribution but increases their cellular accumulation.
Cellular accumulation studies were performed in confluent MDCK-MDR1 and Caco-2 cells.
The higher cellular uptake of the nanoparticulate formulation versus native 6-coumarin could be explained on the basis of the increased cellular accumulation of the encapsulated dyes.
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