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Compared with exponential population growth unaffected by any pheromones, multicellular simulations with interacting cells show significantly reduced cell numbers, i.e. the mean cell cycle duration is increased.
In the model, cell division occurs throughout the epiblast at a homogeneous rate corresponding to a mean cell cycle time of 6 hr (Derrick, 1937; Stern, 1979; Sanders et al., 1993; Voiculescu et al., 2007; Chuai and Weijer, 2009).
In Table 4, the mean cell cycle delay following IR treatment in 21 heterozygous BRCA1 mutation carriers was not significantly different from that in controls using all four parameters.
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Benign tumours and the different types of malignant tumours have mean cell-cycle times about half those of the normal mucosa.
Ignoring these two outliers, the mean normalized cell cycle length is very similar in the two genera (1.8 and 1.9, where the cell cycle length in AB/CD, M, 1M is defined as 1).
In our previous study (Hoose et al. 2012), we found that there was very little correlation between mean cell size and cell cycle progression.
The complex nature of the serum response means that distinguishing cell cycle genes from those involved in wound healing is very difficult.
Other studies have suggested that the rapid degradation of Ccnd1 following environmental stress or DNA damage could be a means of rapid cell cycle arrest to insure DNA integrity [Alao, 2007].
Surprisingly, there was little, if any, correlation between mean cell size and cell-cycle progression.
d Quantification of flow cytometry analysis of cell cycle (mean ± SD, n = 3).
One possible interpretation of these findings is that a hypothetical "tetraploidy checkpoint" [9] would prevent the generation or propagation of tetraploid cells, by mean of a stable cell cycle arrest or their elimination by apoptosis.
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