Exact(2)
More comprehensive models allow direct quantification of flow (F), extraction fraction (E), ve and mean capillary transit time (St Lawrence and Lee, 1998).
Depending on the time interval, the residue function will encompass a vascular and a tissue component: with E the extraction ratio from plasma space to EES, Ktrans the endothelial transfer constant (min−1), ve the fraction of the EES available as leakage space (unitless), and τ is the mean capillary transit time (s).
Similar(58)
Tachycardia may increase TPBT via a decrease in pulmonary capillary transit time [32].
Opposite changes in Dm/Vc ratio were observed and participants decreasing Vc showed reduced alveolar blood capillary transit time.
Indeed, for [11C]raclopride, having a plasma protein binding of 96%, the first pass extraction is about 20%, indicating sizeable dissociation during the short capillary transit time [13].
The application of different biophysical models provides insight into traditional hemodynamic parameters (e.g., cerebral blood volume) and more advanced parameters (e.g., capillary transit time heterogeneity).
We suggest that this difference, which is consistent with functional magnetic resonance imaging (fMRI) data, may be attributable to different capillary transit times in these cortices.
For simplicity, we described the distribution of capillary transit times across the capillary bed by a realistic distribution, for which CTH is simply the standard deviation of capillary transit times, whereas the mean erythrocyte transit time (MTT) is given as the capillary blood volume fraction divided by TBF.
Tachycardia may increase TPBT via a decrease in pulmonary capillary transit time [ 32].
The heterogeneity of capillary transit times during rest and their homogenization towards high flow rates may be a passive effect of capillary bed topology and morphology [ 85, 86].
We used the accepted gamma variate function, according to which CTH is introduced as a single parameter, namely the standard deviation of capillary transit times.
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