Studies have demonstrated in humans [ 26], rats [ 27] and goats [ 28], and have suggested for horses also [ 29, 30], that peripheral tissue diffusion limitation at Vo2max requires that mean muscle capillary pressure head for diffusion, and hence, P v ¯ O 2 and S v ¯ O 2, must be higher to increase O2 flux for a given muscle diffusing capacity for O2.
In the simulation model, gas and oil were considered as the miscible components that mean that there was no capillary pressure between the oil and gas.
Despite these modifications, the methods fundamentally differ in the way they capture the interface, as well as in the number of equations solved and in the way the mean curvature (or equivalently capillary pressure) is computed.
Patient characteristics and vital parameters (heart rate, systolic and diastolic blood pressure, mean arterial pressure, capillary refill time, oxygen saturation, respiratory rate and lactate concentration (arterial or venous sample)) were registered at baseline.
Table 1 Mean values for mean pulmonary arterial pressure (MPAP), pulmonary capillary pressure (PCP), and pulmonary artery occlusion pressure (PAOP) in several clinical studies that studied these parameters in ARDS patients.
Consistently greater decreases in pulmonary capillary wedge pressure, mean right atrial pressure, and pulmonary and arterial pressures with tezosentan did not reach statistical significance.
The following variables were recorded: PAP (systolic, diastolic and mean), mean pulmonary capillary wedge pressure (PCWP) and mean right atrial pressure.
Furthermore, levels of BNP have been demonstrated to correlate to mean pulmonary capillary wedge pressure as an indicator of left ventricular end-diastolic pressure in patients with acute dyspnoea [ 8].
ANP, meanwhile, decreases pulmonary capillary wedge pressure, central venous pressure, mean pulmonary arterial pressure, pulmonary vascular resistance index, and systemic vascular resistance index [ 21, 32- 34].
One parameter indicates the pore size distribution considering the curvature of capillary pressure curve, and other one specifies the mean of entry capillary pressure, i.e., the actual level of the capillary pressure.
