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The mean BMI was similar for the cancer group and the controls, as was mean breast volume.
BMI, height and number of pregnancies were insignificant effects, and mean breast volume and parenchyma type were of borderline significance (results not shown).
When age at menopause is included in the model body mass index (BMI), height, number of pregnancies and parenchyma types P1 and P2 become insignificant, and mean breast volume and parenchyma type DY have borderline significance.
Many of the risk factors for breast cancer are interrelated, so the cancer group and controls were entered into a conditional logistic regression analysis, firstly with independent variables absolute breast FA, family history, mean breast volume, BMI, height, age at menarche, number of pregnancies, menopausal status and parenchyma type and secondly with relative breast FA in place of absolute FA.
We calculated the sample size needed to detect a minimum of 20% difference in breast volume between nulliparous and parous women with and without the 19-repeat allele, with 80% power and an alpha value of 0.05, assuming a mean breast volume of 900 cm and a standard error of 250, and that 50% of the women were parous and equally distributed between the two genotypes.
Similar(55)
Average breast volume can range from 150 cm3 to over 2500 cm3, with an average value of ~ 700 cm3 [12].
The mean difference in breast volume between randomised and nonrandomised patients was 596 cm3 (P < 0.0001, 95% CI = 530 to 662 cm).
Mean percent dense breast volume was 27.6 % (standard deviation, 20.5) (Table 1; full distributions of breast density metrics and BMI are shown in Figures S1a and Figure S1b in Additional file 1).
Given the high correlation between measures of the right and left breast, we computed mean values for total breast area, breast volume, FGV, and %FGV.
Geometric means of standardised breast volumes and 95% prediction intervals were calculated.
The fibroglandular tissue was then segmented within the breast volume using an atlas-aided fuzzy C-means algorithm [ 29].
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