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The mean bout duration was 6.3 weeks (95% CI 5.5 7.0 weeks) among the 285 individuals with episodic cluster headache.
In addition, we found no difference between genotypes in the distribution of wheel running bout durations or the mean bout duration (mean bout duration WT: 90.9±14.4 s vs. DKO: 84.3±10.6 s; p>0.05).
However, neither the mean bout duration was altered (p>0.05 2-way ANOVA), nor was the distribution of arrest durations (Fig. 7C) altered, even though the number of arrests was increased (K-S test P>0.05).
The proportion of time spent in REM, NREM, and waking (and mean bout duration for each state) was calculated separately for baseline, MD, and post-MD sleep periods using standard conventions.
Mice whisked in bouts (mean bout duration, 261 ms; peak-to-peak amplitude, 15.7°; frequency, 15.4 Hz) interspersed with periods of rest.
This minor difference notwithstanding, it is stressed here that this model can reproduce the quasiperiodic pattern of ultradian rhythms in sleep and wakefulness, when using values of Pws and Psw calculated from mean bout duration data in the literature, assuming multi-exponential state transition dynamics and an assumed threshold hysteresis of 0.5 h.
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Mean bout durations were similar to the ones recorded during the nectar foraging observations (27.9±2.1 min).
Mean percentages and mean bout durations of sleep/wake data were either compared for the entire 8-h post-MD period (Fig. 1), or were analyzed using two-way repeated measures ANOVA to test for effects of drugs over time (Fig. S1, Table S1).
Frequency of lying bouts decreased (estimate = −1.90 ± 0.63 bouts/d) and average bout duration increased (estimate = 15.44 ± 3.02 min) with the use of deep bedding.
Mean rumen pH as well as bouts, total h, mean bout length, total area, and mean bout area under pH 5.6 did not differ among treatments.
We were able to record bouts containing ≥ 8 great calls from seven females, all from the wild population (mean: 9.9 calls per bout; range: 8 12, mean bout length 32.8 min, range 12 54 min).
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