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Student t-test was used to examine the mean birthweight difference between twins born in 1991 94 and 2010.
As the cohort went on to birth it was noted that babies born to mothers who described increased fetal movements with hunger were smaller than those that did not describe this pattern (3221.75 g vs. 3583.75 g) with a mean birthweight difference between groups of 364 gm.
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Thirdly dichotomisation is used to provide estimates that are more clinically meaningful for example in comparing two groups when a difference in say, mean birthweight in two groups may be difficult to interpret while a difference in the proportion with low birthweight is intuitively more meaningful.
There were no statistically significant differences for the neonatal outcomes, except for admission to SC and mean birthweight.
Secondary outcomes were preterm births and mean birthweight.
After consistent increases in mean birthweight from 1980 until the mid 1990s, mean birthweight has stabilised over recent years making the new charts appropriate for current use.
The primary outcome measures of the study were LBW and mean birthweight.
In the last decade mean birthweight in all births increased despite the parallel increase in the percentage of preterm births.
For term births, mean birthweights in non-smokers consistently decreased with severity of PIH.
A sample size of 143 in each group will have 80% power to detect a difference in mean birthweight centile of 0.33 SD (the difference between a placebo mean of 4.0 kg and a metformin mean of 3.8 kg) at the 5% significance level (2-sided) using a two group t test; a sample size of 163 in each group will give the study 85% power to detect these differences.
The distribution of GA or mean birthweight did not differ systematically between the two groups from 1978 to 1981.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com