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We identified a total of 11 CpGs differentially methylated between the laboratories/platforms (p-value <0.01 and difference between mean beta values >0.2).
For that purpose, using an in-house program (DataZ), mean beta values were extracted for all subjects using a 5mm radius sphere around activation peaks of interest.
We then compared the mean per CpG in each group with the mean per CpG in each of the other groups and identified genes showing differential methylation (defined as a difference of mean Beta values above 0.5) (Figure 1).
Therefore, a second criterion was used in which clear differential methylation was defined as a mean Beta values between tumors and controls showing a difference of at least 0.5.
Mean beta values for 167 probes distinguishing four consensus clusters.
There was no significant difference in the mean beta values at SREBF2.
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Compared to sham, "dual responders" and "anodal responders" were characterized by mean beta value increases of 86±55%5% and 126 ± 55%, respectively.
In our series, although MOS is more frequently hypermethylated in ALL (mean beta value = 0.64) than in AML (mean beta value = 0.48), it also shows significant hypermethylation in AML.
The value of y(1), at outcomes which are certain, was approximated by the mean beta value of the BOLD response for those trials in the NOM condition in which the probability of winning the lottery was 0.99.
The mean beta value was extracted from each ROI following each switch type.
The global methylation in each sample was calculated as the mean beta value of all CpG sites.
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