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Mean baseline sampling times in high-risk and control offspring.
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This means that baseline sample size to be recruited at each centre is N = 77 (after rounding to the next higher integer).
The mean baseline OKS in this sample was 29, compared to the mean preoperative OKS in the developmental study sample of 17 (when transformed to the 0 48 scoring system).
Amplitude was measured as the peak amplitude from sample mean baseline.
above the mean baseline for each separate sample.
It is important to note that mean baseline age for this sample was aged 78.
The HRSD has a maximum score of 57; the mean baseline score in this sample was 14.6 (s.d. = 14.1).
Effect size ("d") was calculated by using the method for paired samples: mean baseline scores minus mean follow-up scores, divided by the pooled standard deviation.
This study also demonstrated a significant effect of the intervention despite higher baseline scores in this sample (mean baseline scaled score 85.3, compared to 77.2 in the previous study).
The data was normalised and analysed using Normalise Suite v2.4 [ 42], all regions of loss or gain were determined as those that were 2 standard deviations above the mean baseline for each separate sample.
This would have been missed when only comparing the mean baseline score of the sample with the mean score after treatment, since this would have probably resulted in a positive mean change score, falsely indicating improvement for all patients in the sample.
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