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Trend statistical analysis revealed a significant decrease in susceptibility in ED Enterobacteriaceae to eight of 15 (53%) tested antimicrobials, with a mean annual decrease of 1.6%±0.6%, in the ICU isolates, a significant decrease was detected in only five (33%) of the tested antimicrobials, with a mean annual decrease of 2.5%±1.3%.
While the number of units showing significant trends decreased, the magnitude of the decrease actually grew for that subsample: the median decrease was 3.5percentt per year while the mean annual decrease was 3.7percentt.
A study using a French update of the Beers 1997 [ 29] criteria showed a mean annual decrease in PIM rate of 3.6%% between 1995 and 2004 [ 57].
Analogous findings were observed in a model of associations between primary kidney disease and mean annual decrease in eGFR (Table S3) and in analyses excluding participants with diabetes from the other recorded diagnoses group (data not shown).
In the population aged 35-65, where long term trends can most reliably be assessed, an overall 1.1% mean annual increase is observed for males and a 0.6% mean annual decrease is observed for females.
In patients aged 24 years or younger (n = 55), there was a mean annual increase of 2.9%9595% CI 1.6%to4.2.2%) at the distal forearm, but a mean annual decrease of 2.5%9595% CI -3.8%to-1.2.2%) athehe femoral neck and a decrease of 2.2%9595% CI -3.3%to-1.0.0%) for the total hip (p < 0.001 for all analyses).
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Mean annual temperatures decrease with elevation by 0.58°C/100 m and mean annual precipitation increases with elevation by 4.3%/100 m (Wang et al., [2001]).
Mean annual temperatures decrease from 24 (^{circ } mathrm{C}) in the lowlands to 12 (^{circ } mathrm{C}) at ca 2000 m.
Supplementary Table S3 (PDF) Effect of adjustment for known risk factors on mean annual eGFR decrease by cause of kidney disease.
The decrease in the maximum harvest intensity is also logical because the effect of the initial growing stock on mean annual harvest decreased when the length of the time horizon increased.
For the 33 catchments, the mean annual runoff decreased by 43.0 mm from the period-1 (91.4 mm) to period-2 (48.4 mm).
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