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The mean administered activity was 231 MBq.
The mean administered activity was 141 ± 8 MBq (range, 133 to 148 MBq).
The mean administered activity was 141.5 ± 6.7 MBq with a mean injected volume of 1.8 ± 0.4 mL.
In total, 50 patients with mCRPC and treated with 177Lu-PSMA-617 (mean administered activity 6.3 ± 0.5 GBq) were retrospectively included in a bi-centric study.
All patients received CBC, renal and liver function tests the day before and 2 days after application (mean administered activity 5.6 GBq, range 4.1 6.1 GBq), followed by further tests every 2 weeks.
To check the accuracy of dilution and decay calculations, serial gamma counter measurements of radiation delivery were taken on each day of administration and revealed a high degree of consistency in actual administered activity for the fractionated therapies, with mean administered activity of 98.4% of baseline with a standard deviation of 3.5%.
Similar(53)
The curvature of the plot of NECR against administered activity means that this requires an activity of 365 MBq, an increase of 54%.
Priming resulted in higher mean absorbed dose per administered activity for the adrenals, lungs, pancreas, and spleen.
The maximum uptake by red marrow was about 2% of the injected activity, and the mean absorbed dose per administered activity was 2.26E-2 2.26E-2-3 mGy/MBq.
Radiation dosimetry analysis showed that the mean absorbed dose per administered activity was 4.5 and 2.3 times higher in the liver and kidneys, respectively, than in PCa lesions.
The mean absorbed dose per administered activity (Gy/GBq) to the right and left kidneys for each patient given for each treatment cycle (1 to 5 per patient).
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