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Adipocyte enlargement is limited; an overfeeding study in Pima Indians showed 3-kg weight gain but a reduction in mean adipose cell size, with a 50 100% increase in the number of small cells (27).
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Representative mean adipose cell-size distributions (see Materials and Methods) comparing treated and control rats on days 0, 16 and 24 are shown in Figs.
We elucidated a significantly increased mean subcutaneous adipose cell size [+0.32 ρL] is these participants subsequent to 8-weeks of caloric excess.
"We used to think of an adipose cell as an inert storage depot," Dr. Kahn said.
The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity.
Smoking cessation was not associated with a change in adipose cell size (μg triglyceride/cell).
(a) Optical picture taken with a conventional brightfield microscope showing an adipose cell.
Figure 5: Imaging of an adipose cell using ~5 GHz phonons.
Shepherd, P. R. et al. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.
Much of this literature draws conclusions from studies of the mean sizes or other averaged characteristics of adipose cells.
(a) Epididymal adipose tissue; (b) Sections of epididymal adipose tissue stained with hematoxylin and eosin (H&E); (c) Body fat rate; (d) CSA (cross sectional area) of epididymal adipose cells; (e) Adipose TG (triglyceride); (f) Adipose TC (total cholesterol).
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