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We calculated mean adherence based on self-report and on pharmacy refill data.
Despite ideal conditions and regular follow-ups, mean adherence based on pill intake recall, in both groups was approximately 50%.
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Once-daily treatment with MF-DPI also significantly improved mean adherence rates based on patient self-reports compared with twice-daily MF-DPI, as well as mean adherence rates based only on those patients who received and returned all 6 canisters of study medication.
Mean adherence rates based on self-reports were also significantly better (P < 0.001) with MF-DPI 400 μg QD PM (97.2%) than with MF-DPI 200 μg twice-daily (95.3%).
There was no significant difference in mean adherence scores based on the ADQ reports of children/adolescents (4.0173 ± 0.56) or caregivers (4.0196 ± 0.59, P = 0.90, r = 0.0002), indicating that parents and children/adolescents are in fairly good agreement concerning their perceptions of the adherence behavior.
(2) We determined adherence based on the number of refills.
For example, we defined adherence based on 365 days.
To study the association between the adherence-enhancing components and their effect on adherence, a linear meta-regression model, based on mean adherence point estimates, and a meta-analysis were conducted.
This definition of a day was calculated by removing days that were lower than 1 SD below the mean (based on a mean adherence of 15.8 ± 3.4 hrs/day).
Based on the mean adherence rates in the control groups, mean SDs and the effect size calculated, it has been possible to estimate the increase in percentage of doses taken for the intervention groups.
Based on MEMS adherence records, mean adherence for the 30 days prior to the first and second pharmacokinetic study visits was 99.7% and 99.0%, respectively.
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