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The overall mean adherence among the ART-experienced was 87.5% (IQR: 70.5%–96.8%).
At randomization, mean adherence among intervention and control subjects was comparable at 86.8 and 83.8%, respectively (t-test statistic = −0.59; P-value = 0.56).
This study has demonstrated that a simple intervention involving monthly adherence counseling based on EDM feedback significantly improved mean adherence among Chinese ART patients.
However, at month 12, mean adherence among intervention subjects was much higher than among controls: 96.5 vs. 84.5% (t-test statistic = −3.20; P-value = 0.003).
Some experts argue that setting a high standard for adherence is discouraging to patients, and alternative levels such as 80% or simply mean adherence among patients could also be used in an analysis [ 35]. *The annual cost of a $20,000 training with a four-year life of investment is $5,000.
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The mean adherence was highest among the poorest (78.4%), followed by the richest (76.6%), richer (70.9%), middle (70.3%) and poorer (54.9%) (Data not presented in Figure).
At month 12, among 64 subjects who completed the trial, mean adherence had risen significantly among intervention subjects to 96.5% but remained unchanged in controls.
Cramer found mean adherence rates of 58%and65%5% among patients with psychiatric disorders and depression, respectively [ 11].
In literature an estimated mean adherence rate of 55% among pregnant women taking prenatal multivitamins is reported [ 14]; thus a higher FA supplementation could better maintain the serum folate concentrations.
When all populations were combined, mean adherence was slightly higher among participants following once-daily regimens than those; following twice-daily regimens (WMD = 2.55%; 95% CI, 1.23 3.87; P =.0002; Figure 3).
Among randomized subjects, mean adherence and CD4 count were 86.8 vs. 83.8% and 297 vs. 357 cells/μl in intervention vs. control subjects, respectively.
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