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The mean activity across all tested cell lines was significantly above the negative control in 15 out of 21 promoters suggesting that the majority of the cloned regions have measurable promoter activity (Figure 4A).
Data from seven cell lines are presented along with the mean activity across the whole panel (MGM value).
For each participant, the slope of the mean activity across conditions was calculated by fitting a regression line to the mean beta value from each condition (assuming an equivalent interval between all conditions, for discussion of this assumption, see Supplementary Methods).
Analyses were performed only on voxels showing an increase in the mean activity across conditions from baseline during search using a mask that contrasted BOLD activity during the encoding phase against baseline activity (load 1/ES encoding + load 3/ES encoding + load 5/ES encoding + load 1/DS encoding + load 3/DS encoding + load 5/DS).
HS5 cells had the lowest activity (2460 pmol PAR/10 cells) and the NGP cells had the highest activity (85 750 pmol PAR/10 cells) with the mean activity across the panel being 18 069±18 679 pmol PAR/10 cells (mean±s.d).d
One example summarized in [ 56] shows, in the case of predicting age, the mean activity across the entire brain gives better predictive power over more complex approaches, yet when predicting diagnosis, a connectivity-based measure was more informative than the simpler measures.
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Activity values (beta values from each participant's GLM) were extracted from each ROI for each condition and the mean activity value across all ROIs was computed for each participant.
As a first indication of the population PFC response in fixed- and cued-target tasks, Figure 3 shows mean activity at each task phase, across the full set of 217 stimulus-related cells.
The average response to choice stimuli was remarkably similar in fixed- and cued-target tasks, with no hint of significant difference across the cell population (ANOVA across cells on mean activity in window 50 500 ms from stimulus onset, factors task × hemifield × serial position, main effect of task P > 0.2).
In the cued-target task, there were phasic responses to both cue and choice stimuli, the former rather smaller (ANOVA across cells on mean activity in window 50 500 ms from stimulus onset, factors stimulus (cue/choice) × hemifield, main effect of stimulus P < 0.001).
c Mean activity concentration of the 37 mm VOI within the warm background compartment of the phantom compared to the true activity concentration, averaged across the eight sites.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com