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Parameter estimates were reliable with small RSEs (Table 2), except for the mean absorption transit time which displayed a high RSE (106%) as few samples were collected during the absorption phase.
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The first order absorption transit rate constant was estimated to be 9.2 h–1 for LCIG and 2.4 h–1 for LC-oral (corresponding mean absorption time of 7 min for LCIG vs. 25 min for LC-oral; estimated from the entire pharmacokinetic dataset regardless of food intake for both treatments).
mean absorption coefficient.
k∗ mean absorption coefficient (m−1).
Its reciprocal is called mean absorption length.
The model consisted of a one compartment disposition model with absorption transit compartments.
As such, RIF PK was described using absorption transit compartments and a one compartment distribution model coupled with an enzyme turn-over model.
By this approach, a mean 3H transit time of 4.6 years for the fissured-porous karst aquifer was determined, whereas the fast flowing water in the conduit system showed a mean transit time of days.
The mean pulse transit time did not show any change after noise exposure (p = 0.450).
A transit compartment model estimating both the mean transit time and number of transit compartments resulted in a flexible absorption model that well described the rich data during the absorption phase.
The rank order of the means of β was CO < FDG ≈ MG < FDGal < H2O, reflecting their different splanchnic mean transit times.
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CEO of Professional Science Editing for Scientists @ prosciediting.com