Sentence examples for mdr it from inspiring English sources

Though dAFT-MDR is based on a binary value as the original MDR, it can adjust the covariate effect using the standardized residual of the AFT model, whereas the original MDR cannot adjust the covariate effect.

Therefore, to overcome MDR, it is important to understand how this transporter exerts its function and how its expression is regulated, as this information may provide clues for developing compounds that modulate BCRP activity.

Although researches have advanced greatly in MDR, it remains a formidable problem in clinical treatment.

Unlike ordinary MDR, it can identify single‐locus effects or joint effects of multiple loci in families of diverse structure.

Sixth, although the Haarlem strain was MDR, it was able to cause an outbreak in those vaccinated with bacille Calmette-Guérin and in persons who were not hospitalized.

Given the well-known role of P-gp in MDR, it was expected that the activity pattern of confirmed substrates (e.g., geldanamycin, paclitaxel, doxorubicin and vinblastine) would show an inverse correlation to P-gp expression.

Also for MB-MDR it has never been investigated what the cumulative effect is of violated association test assumptions, acknowledging that the presence and extent of these violations may differ within and between several stages of the MB-MDR analysis.

MDR and it's family-based compliment, the MDR pedigree disequilibrium test (MDR-PDT) [8] are nonparametric methods that do not require the specification of a genetic model profiling risk or the estimation of any population parameters.

A bacterium was characterized as MDR when it was resistant to three classes of antibiotics and as MDRc when it was also resistant to carbapenems.

Unfortunately, the quercetin conjugates were not as effective as verapamil in Pgp-inhibition and thereby reversing MDR, but it is worth to note that the structurally modified quercetin conjugates with a non-cleavable linker showed significantly improved MDR-reversal activity compared with quercetin.

This review focuses on recently published literature about nanosystems with endogenous stimulus-responsive features to overcome MDR, and it discusses their design and stimulus sensitivity, as well as their in vitro and in vivo anti-tumor efficacy in MDR tumors and cells.