Sentence examples for mcl i from inspiring English sources

We observed that an MCL I parameter of 1.2 and 1.3 produced the best clustering solution in terms of enrichment significance for GO biological process (BP) in most cases (Table  1).

Figure 3 shows that in the two highest Latino quartiles, proportionately more systems had average nitrate concentrations > MCL (i.e., 5% and 7% in the two higher quartiles compared with 0% in both of the lower quartiles).

Cell synchronization was monitored by propidium-iodine (Sigma-Aldrich, St Louis) staining flow cytometry analysis on a Beckman-Coulter XL-MCL I single laser cytometer (Miami).

Following manual assessment, the clusters generated with inflation 1.2 (–blast-ecut = 1e-2 –mcl-scheme = 7 –mcl-I = 1.2) were used for further analyses.

However, we have previously shown that inhibitors of BCL-2/BCL-XL but not of MCL-1 (i.e., ABT-263, low Sabutoclax concentrations) do not enhance lapatinib toxicity, arguing that inhibition of MCL-1 is essential to promote killing by this RTK inhibitor.

The graph partitioning procedure, using default MCL parameters (I = 2), generated 11 highly homogeneous clusters (Fig. 1C F).

In fact, higher XPO1 expression at diagnosis was associated with a poorer prognosis in MCL patients (i.e., a median overall survival of 3.2 years in the low expression XPO1 cases vs 1.9 years in the high expression XPO1 cases, P = 0.033) (Fig. 1a).

In ambulatory animals treated with IGF-I and unloaded animals treated with IGF-I or GH+IGF-I, MCL matrix organization was greatly improved.

Exposure of RCCs to the combination of agents caused a large increase in the phosphorylation of PERK and its downstream substrate eIF2α, which was directly associated with reduced expression of MCL-1 and BCL-XL.,, MCL-1 in particular has a short half-life and reduced MCL-1 production i.e., due to eIF2α phosphorylation, will rapidly reduce MCL-1 protein levels (Fig. 8).

k, top k HRR for a given gene-centric cluster; I, MCL inflation parameter.

The inclusion criteria were (i) MCL stage II-IV, (ii) previously untreated, (iii) CCND1 positivity or presence of t(11 14) and (iv) age 18 65 years.