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It also decreased time in and entries into the open arms of the elevated plus maze compared to handled controls, suggesting enhanced anxiety-related behavior.
Consistent with previous studies, we found that 400 ng CGRP infused bilaterally into the BNST increased the acoustic startle response and induced anxiety-like behavior in the elevated plus maze compared to vehicle.
The finding -- off of which headlines such as "Drinking three glasses of Champagne every week 'could prevent dementia'" were based -- was that five of the eight champagne-drinking rats successfully completed the maze, compared to an average four in the other groups.
We found that exclusively pre-weaning enrichment significantly improved performance on the Morris water maze compared to non-enriched mice.
At Baseline, the older wild-type fish showed increased consecutive choice of the same arm of the maze, compared to young animals.
Female transgenic mice displayed increased amounts of head dips and open arm time on the maze, compared to littermate controls.
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α-CaMKII hKO mice showed significant impairment in the Y-maze compared to controls (t = 3.62, df = 14, p < 0.01; Fig. 3A), as did pilocarpine-treated mice at a 30-sec delay (t = 2.34, df = 10, p < 0.05; Fig. 3B).
Both the hexagon maze and radiolarian maze yielded similar results for reductions in working memory errors, and for neighbouring arm biases, suggesting that the greater geometric complexity of the mazes compared to the classic maze can reduce the behavioural biases observed on the latter.
Treatment with Curcumin extract (10 and 20 mg/kg, ip) for 5 days significantly prevented weight loss, impairment in locomotor activity, anxiety like effects in all behavioral paradigms tasks (mirror chamber, plus maze, zero maze) as compared to control (72-h sleep-deprived) (P<0.05).
While mice, lacking CCK2 receptors, housed in standard conditions were more anxious, displayed stronger restraint-induced analgesia and performed worse in the water maze when compared to corresponding wild-type littermates, none of these phenotypes were observed in mice, housed in enriched conditions.
Behavioral tests performed when the rats were fully mature demonstrated that they were more aggressive when handled, more active in open field, and had deficits in learning platform position in the water maze as compared to controls.
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