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Anxiety-related behavior was assessed with the elevated-plus maze, and spatial learning and memory were assessed with the Morris water maze.
Spatial reference memory was evaluated using the Barnes circular maze and spatial working memory was tested using the eight-arm radial maze.
Impaired navigation in the water maze and spatial alternation in the T-maze suggest an alteration in hippocampus-dependent encoding and/or consolidation of spatial information, in line with the synaptic and neurophysiological alterations observed in Dp71-null mice in this structure.
In both hyperammonemic and PCS rats, GR3027 restores motor coordination, spatial memory in the Morris water maze, and spatial learning in the radial maze.
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Pothion and colleagues [21] investigated three different mouse strains in terms of sucrose consumption, body weight changes, coat state, spontaneous alternations in the Y-maze and spatial learning in the Morris water maze test.
BDNF levels are directly correlated with the animal's performance in the water maze [71] [78], and spatial learning induces BDNF production/expression in the hippocampus [79] [81].
They also exhibited a substantial spatial learning deficit, both in the water maze and during spatial nonmatching-to-place testing on the elevated T-maze.
CaMKIV KO mice exhibited intact spatial reference memory learning in the Barnes circular maze, and normal spatial working memory in an eight-arm radial maze.
We then examined the relationship between the brain c-Fos expression after the Y maze and the spatial memory performance in this task.
The previously reported impairment in OFC-lesioned rats on the spatial version of the intertemporal choice task is unlikely to reflect a general problem with spatial learning, because OFC lesions were without effect on acquisition of the standard reference memory water-maze task and spatial working memory performance (nonmatching-to-place) on the T-maze.
With this aim a four-arm plus-shaped maze and a reference spatial memory paradigm were used, in which the goal arm was marked in two ways: by a prominent extramaze cue (intermittent light), which maintained a constant relation with the goal, and by the extramaze constellation of stimuli around the maze.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com