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The data suggest that miR394a does not function in parallel to ABI4 and ABI5, but both ABI4 and ABI5 may work downstream of miR394a.
The effect-reducing allele of qSD7-2/qPH7 blocked the GA responses of the qSD1-2/qPH1 wild type (i.e., 1+1+7−7− < 1+1+7+7+), including Amy1A's transcription, suggesting that qSD7-2/qPH7 may work downstream of qSD1-2/qPH1 to regulate plant height and seed dormancy (refer to Figure 9).
Upon deletion of Gata3, cochlear wiring is severely disrupted and SGNs fail to express a cohort of auditory-specific genes (Appler et al., 2013; Duncan and Fritzsch, 2013), including additional transcription factors that may work downstream of Gata3 to direct specific features of SGN differentiation.
In contrast, the effect-reducing allele at qSD7-2/qPH7 was derived from the weedy line; this allele was GA-insensitive and blocked GA responses of qSD1-2/qPH1, including the transcription of a GA-inducible α-amylase gene in imbibed endosperm, suggesting that qSD7-2/qPH7 may work downstream from qSD1-2/qPH1 in GA signaling.
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On a physiological level beyond conscious perceptions, some CR mimetics may need to work downstream of hunger signals to be effective.
Since these overexpressing plants accumulated nearly wild-type levels of free SA, WRKY25 may work at a point downstream of SA to repress defense responses.
These studies suggest that DUSP6/MKP-3 is a negative regulator of FGF signalling during vertebrate development, which may work to set the levels of ERK signalling downstream of this signalling pathway.
To integrate the scaffolding function and the Mec1 Ddc2 activation function of Dpb11 into a mechanistic model, we hypothesized that Dpb11 may work by activating Mec1 Ddc2 and bringing active Mec1 Ddc2 into proximity with one of its key downstream targets, Rad9.
Thus, drug targets or disease genes may work as driver factors in transcriptional level, which propagate signals through gene regulatory network and cause the downstream genes' differential expression.
Drug targets and disease genes may work as driver factors at the transcriptional level, which propagate signals through gene regulatory network and cause the downstream genes' differential expression.
But it may work.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com