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Category Cs, like Retin-A, have demonstrated an adverse effect on animal fetuses, but, according to the F.D.A., "the potential benefits may warrant use of the drug in pregnant women despite potential risks".
Potential benefits may warrant use of the drug in select pregnant women with severe disease despite the known potential fetal risks.
The Food and Drug Administration FDAA) has evaluated cyclophosphamide as Category D, indicating positive evidence of human fetal risk, but potential benefits may warrant use of the drug in pregnant women despite potential risks [ 33].
If the point estimate of the relative rate for each transition in the multistate model were similar, and if the estimates of the baseline rate functions for each transition were also similar, then this may warrant use of simpler models.
Subsequently, due to retrospective and prospective case reports of neural tube defects in humans with first-trimester exposure to efavirenz, the FDA reclassified the drug as class D (there is positive evidence of human fetal risk based on studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks).
Category C is for drugs where animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in human, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Similar(52)
The higher incidence of metastasis may warrant the use of postoperative chemotherapy, a protocol not used in this study.
Extensive errors found in random-mer molecular barcodes may warrant the use of error correcting barcodes for transcriptome analysis as input amounts decrease.
This reduction may warrant the use of IMRT for younger patients who have a statistically significant risk of contralateral breast cancer associated with breast radiotherapy.
This possibility reduces the level of confidence for confirming a mono-specific DFS70 reaction and may warrant the use of a second confirmation step for DFS70 and/or multiple confirmatory assays for other ANAs.
Based on our findings, such appropriateness in medication may warrant the use of two or more antibiotics especially for cases in which both Gram-positive and Gram-negative pathogens are involved.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com