ESR1 is an attractive candidate, the binding of which may underlie several diseases showing marked gender disparity.
Yeo and colleagues [ 50] have proposed that properties related to increased developmental instability may underlie several of the features of schizophrenia, including increased minor physical anomalies, increased dermatoglyphic FA, and loss of normal cerebral asymmetry.
Nevertheless, the deficiency in bioenergetics in PMN described here may underlie several impairments noted in PMN function in aging and may also contribute to enhanced susceptibility to infections, pulmonary congestion, or recovery from burn injury noted in aging [ 9, 41, 42].
It is possible that saturated fat intake may underlie several of these associations, as we previously reported an increased risk of pancreatic cancer for greater intake of total and saturated fat in this population [ 20], and pure or mixed chocolate bars are high in fat content.
It is well known that an imbalance of excitation and inhibition may underlie several neurological diseases, such as autism (Rubenstein and Merzenich, 2003), Tourette's syndrome (Singer and Minzer, 2003), schizophrenia (Wassef et al, 2003) and Down's syndrome (Fernandez et al, 2007).
In addition to this aspect, our findings have important implications: (1) Mutations that disrupt the tight control of aggregation-prone proteins, thereby altering the dynamic equilibrium between the soluble monomeric and aggregated states, are likely to be a common mechanism that may underlie several expression level dependent disease phenotypes that involve protein aggregation.
Accumulating evidence also suggests that autophagy impairment may underlie the etiology of several neurodegenerative diseases.
GSTO1 has diverse functions, including mitigation of oxidative stress, and may underlie the pathophysiology of several neurodegenerative diseases.
Indeed, there is increasing evidence that defects occurring during embryonic development lead to impaired functioning of the cerebral cortex, and that such defects may underlie the etiology of several human pathologies, including schizophrenia and autism spectrum disorders.
An increasing number of evidences support the view that the coordination between mitochondrial ATP supply and mechanical activity demand is highly dependent on an efficient Ca2+ transfer from SR to mitochondria, and that altered SR mitochondria Ca2+ exchange may underlie the pathophysiology of several cardiac diseases.
Several reasons may underlie the greater sensitivity of primary midbrain neurons, as opposed to astrocytes, to death via oxidative inactivation of m-aconitase.
