Sentence examples for may underlie phenotype from inspiring English sources

These authors also used chromatin interaction analysis with paired-end tag sequencing technology (ChIA-PET) to find that many GWAS variants within DHSs were highly associated with the activity of distant genes, some of which were at distances of more than 500 kb from the transcription start site; these non-coding variants may underlie phenotype associations in autoimmunity.

These results indicate that TACC3 is involved in cell migration and they open the possibility that the +TIP behavior of TACC3 may underlie this phenotype.

Although the authors suggest that the cryptic deletion of CNTNAP5 may underlie the phenotype seen in this patient, the complexity of the genomic rearrangement complicates interpretation.

Our findings demonstrate a consistent pattern of functional deficiency and provide further support for a helicase-dependent cellular function of RECQL4 in addition to its Nterminus-dependent role in initiation of replication, a function that may underlie the phenotype of RECQL4-linked disease.

In addition, since Rtg1-3p and Msk1p are, respectively, positive and negative regulators of the RTG pathway, the fact that deficiency in any of them results in a resistance phenotype suggests that other functions of these proteins, and not only regulation of the RTG pathway, may underlie the phenotypes observed.

This indicates different molecular pathways may underlie the phenotypes mapped to chromosome 14 and those mapped to chromosome 15 though they all belong to same category.

These discoveries have yielded important insights into the genetic basis of phenotypic evolution, from understanding how genetic interactions and gene architecture may bias and constrain evolution [e.g., [ 4- 9]] to how cooption and modification of gene networks may underlie novel phenotypes [e.g., [ 10- 12]].

Because of the intimate relationship between miRNAs and EMT signature genes, we believe that an integrated analysis of these two groups of genes (protein coding and non-coding) is critical to define the core regulatory network that may underlie specific phenotypes associated with cancer subtypes.

Striking similarities amongst a range of unrelated domesticated species suggest that similar regulatory mechanisms may underlie the domesticated phenotype.

CONCLUSION:Structural abnormalities in reward regions may underlie the anhedonic phenotype.

Therefore, p53-mediated changes may underlie the common phenotype of mutants for cell-essential genes.