Disrupted RNA splicing and/or nuclear export may underlie C9orf72-ALS pathogenesis.
Missense mutations in the first ZF motif (ZF1) result in defective nuclear localization, which may underlie the pathogenesis of heterotaxy.
Accordingly, mutation in the apoAI gene or, alternatively, the PPARα nuclear receptor itself may underlie genetic susceptibility to paradoxical HDL-C lowering with fibrate treatment.
A cytoplasmic role as an antagonist of Wg signaling and a nuclear role in facilitating TGF-β signaling may underlie the observation that the relative abundance of cytoplasmic versus nuclear SnoN is a prognostic indicator in a subset of tumors [36].
Thus, the regulation of Wnt target genes transcription by nuclear translocation of β-catenin may underlie the increased cell proliferation and neuronal differentiation stimulated by lithium treatment.
And our research suggests there is a further – seriously neglected – factor that may underlie the intense attachment of successive UK governments to civil nuclear power.
Our S2 cell studies point to a delay in nuclear translocation of PER and TIMΔNLS that may underlie the longer period observed in tim ΔNLS mutant flies.
We tested the hypothesis that expression of the receptor for advanced glycation end-products (RAGE), an important signal transduction receptor that elicits long-lasting nuclear factor kappa B (NF-κB) activation, may underlie this difference.
Repeat sequences may attract some specific nuclear proteins, and the chromatin folding code dictates the DNA protein interactions, which may underlie the genetic function of the tandem repeats [58].
Several lines of evidence suggest that segmental packaging of chromosomal neighborhoods may underlie features of chromatin that span large domains, such as heterochromatin blocks, association with the nuclear lamina and replication timing.
