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It now appears that large numbers of very rare genetic mutations may underlie common human diseases like schizophrenia and cancer.
Additionally, processes are identified that may underlie common cancer related phenotypes, such as inflammation.
Although FTLD and ALS can represent as rather distinct clinical entities, the discovery of aggregations of dysfunctional protein together with gene mutations identify them as a clinical continuum which may underlie common pathogenic pathways (1).
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Therefore, p53-mediated changes may underlie the common phenotype of mutants for cell-essential genes.
Several genes constituting part of a HSC 'gene signature' were also identified in our analysis, including MLLT3 and SMARCA2, amplified as a result of trisomy 9 in six patients and PBX1 amplified in three patients on chr1q22 1q25.3, strengthening the hypothesis that aberrant self-renewal may underlie a common MPN progenitor (Table 1).
These co-occurring experiences may reflect underlying common mechanisms which can provide direction for symptom relief.
The common disease common variant (CDCV) hypothesis postulates that common variants with small to modest effects (allele frequencies >1%) may underlie susceptibility to common disorders.
But now scientists are coming to realize that inflammation may underlie many other common chronic diseases that come with aging, including atherosclerosis, diabetes, Alzheimer's disease and osteoporosis.
Finally, Mendelian forms of clefting provide another important avenue for identifying genes that may underlie the more common and isolated forms of clefts, especially if these syndromic forms can occasionally manifest as phenocopies of isolated clefts (e.g. Van der Woude syndrome, VWS [MIM 119300]).
This mechanism may underlie the formation of common chromosomal aberrations and copy number changes seen in human breast cancers.
A common liability may underlie the expression of these disorders in a single externalizing spectrum.
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CEO of Professional Science Editing for Scientists @ prosciediting.com