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Several mechanisms may underlie causative links between OCM disturbances and schizophrenia.
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Paradoxically, knowledge of the underlying causative mutations may lead to the further increase in frequency of the corresponding variants, as it will be possible to avoid at risk matings by marker assisted selection.
This does not preclude that the underlying causative mutation may be in high linkage disequilibrium (as is the case for the JH1 haplotype and the CWC15 gene in Jersey cattle) or not (as the mutation responsible for CVM in Holstein cattle) with the BH2 haplotype.
Furthermore, potential epistatic interactions (i.e. the masking of a gene by the effect of another unrelated gene) may underlie many QTL peaks and congenic intervals [30,31], and this has hampered progress towards the identification of causative genetic elements.
that may underlie these results.
What may underlie this divergence?
As such the association we observe with R61H may not necessarily mean it is the underlying causative variant, and could be tagging one of these two variants or another, yet to be uncovered mutation event.
Identification of the underlying causative gene is therefore necessary and there are a variety of approaches that may achieve this aim, including the use of mouse models.
The only exception to this may be the use of MRI in cases of late onset depression to confirm the presence of underlying causative small vessel disease.
Infection or any underlying causative disorder also must be treated quickly.
However, the underlying causative mechanisms are incompletely understood: this hypothesis proposes one possibility.
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CEO of Professional Science Editing for Scientists @ prosciediting.com