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A recent study has shown that acute CORT treatment (for 7 days) shifts the balance of cell types produced towards fewer neurons and more oligodendrocytes, and has suggested the possibility that this shift may underlie behavioral effects of CORT treatment (Chetty et al, 2014).
iii) what is the functional mechanism that may underlie behavioral changes in dark or complex environments?
Microarray analysis identified a large number of genes that differed among zebrafish populations and may underlie behavioral domestication.
Animal studies and in vitro mechanistic studies are emphasizing the importance of alterations in neurotransmitter systems and thyroid function that may underlie behavioral dysfunction.
We next tested if these behaviorally distinct zebrafish strains also differed in gene expression in the brain to identify genes or pathways that may underlie behavioral variation.
Furthermore, it is also speculated that synaptic plasticity induced by substances of abuse in the neuronal circuits of reward may underlie behavioral changes that characterize addiction.
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These novel findings raise the possibility that GluR5 in the BLA may underlie the behavioral expression of anxiety.
For example, gene expression changes occurring specifically in the brain may underlie adaptive behavioral or physiological responses to the environment.
These functional differences may help explaining why only Rac1N mice show spontaneous epileptic activity, and may underlie the behavioral differences between Rac1N and Rac3KO mice.
Instead, the alterations in brain cytokines, which occurred in a sexually dimorphic manner, may underlie distinct behavioral phenotypes in adult male and female offspring.
Structural or functional changes in one or more of these brain regions, together with their associated circuitry, may underlie the behavioral effects.
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Justyna Jupowicz-Kozak
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