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Alternatively, T cells with higher affinity to MHC may undergo selective expansion via homeostatic induced proliferation in the Foxn1Δ/Δ lymphopenic periphery, where MHCII expression should be normal.
For instance, a mutation that inverts or translocates a segment of micronuclear DNA might result in more effective replication or chromosome segregation in the micronucleus (where genes are not expressed), and it may undergo selective fixation due to this effect.
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The average K a and K s values for the paralogs within species were significantly greater than those for the homologous actin genes from different species within the same group (P < 0.001 for both K a and K s ), implying that different actin genes with distinct functions may undergo diverse selective pressures.
Alternatively, they may be correctly specified but undergo selective cell death early on.
For example, the ecotoxicological impact of the metals may have caused large areas of the genome ('genomic islands') to undergo selective sweeps (Nosil and Feder 2012), and the power of just a handful of genetic markers may not be sufficient to uncover this signal.
Colorectal tumors undergo selective miR-200 hypermethylation, sustaining the association between methylation and differentiation status.
In some parasite lines the development of resistance to antimalarials such as blasticidin and leupeptin has been found to be associated with alterations of a so-called plasmodial surface anion channel (PSAC) [43], [44], indicating the existence of a pathway that involves a parasite-encoded transporter, which may undergo mutations under selective pressure.
Nonetheless, strains may undergo different selection pressures.
Therefore, the genes with excesses of intermediate-frequency SNPs and SMPs may undergo different types of selective pressures on genetic (e.g., balancing selection) and epigenetic (e.g., directional selection) levels.
Selective gene regulation by RIP140 suggests that RA target genes may undergo distinct patterns of dynamic gene expression relevant to the growth suppressive and differentiating effects of RA.
Collectively, these findings suggest that only selective types of DSBs dependent upon their nature or localization may undergo resection, and further work is required to define the precise factors regulating whether or not resection occurs at a DSB.
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