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Additionally, although a patient's tumor lesion may undergo alterations which are characteristics of remission after effective therapy, the symptoms do not typically present in time.
It is also worth noting that stromule formation is strongly induced in plants responding to pathogen infection, and that chloroplast structure may undergo alterations following pathogen recognition [ 31].
As a consequence, the skin may undergo alterations that, in turn, lead to chronoaging, photoaging, inflammation, and immune dysfunction, and all these processes are mediated by reactive oxygen species.
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Epitopes located on the protein may also undergo alterations in the process.
In this regard, monozygotic twins are a good model for studying epigenetic changes linked to aging: they provide evidence that these changes can accumulate over time, as one individual may gradually undergo alterations that his or her twin (with identical genotype) does not (Fraga et al., 2005; Schneider et al., 2010).
When these checkpoints are bypassed the genome may evolve and undergo alterations to a point where the cell can become premalignant and further genome alterations lead to invasive cancers.
The sexual makeup of an entire oyster population also has a seasonal aspect; in harmony with the group, an individual may undergo several alterations in the course of a year.
For example, a recent cancer gene census [6] lists 33 kinases that may undergo genetic alterations in cancer.
Taken together, evidence strongly suggests that glycine and histidine as well as their relevant metabolic pathways may undergo pathological alterations during the development of OA.
The cell-type specific differential binding regions detected by dCaP in cancer cell lines can pinpoint the regulatory loci that may undergo genetic alterations, and hence their nearby target genes may be the potential candidate genes associated with cancer.
Some cells may undergo irreversible alteration at the genome level, some may exhibit changes in their gene expression pattern, while others may incur neither genetic reconstruction nor gene expression changes, but only modulation of various fluxes by changing nutrient/metabolite concentrations and enzyme activities.
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