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However, when suspending the Ag nanoparticles in media 24 h prior to the 2 h testing (aging, see "Using freshly prepared nanomaterial-suspensions may underestimate toxicity" section), a higher degree of reproducibility was obtained.
This suggests that current regulatory practice of assessing risks based on individual compounds may underestimate toxicity.
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Non-dioxin-like PCBs are not included in this approach and TEQ can therefore underestimate toxicity.
Therefore, if the extraction is selective, leaving behind more or less toxic constituents, the toxicity results may underestimate or overestimate (respectively) the toxicity of the original material.
As subacute, subchronic and chronic NOAEL (and LOAEL), expressed as pesticide concentration in feed did not differ statistically significantly, the TMDI as benchmark for the ADI may underestimate the significance of the toxicity of subacute exposure.
The colony-forming assay is known to be a very sensitive method of toxicity evaluation, but it may underestimate early cell survival (Hamdan et al. 1999).
"Thus, animal experiments can over- or underestimate toxicities of chemicals—or give the right result.
Traditional environmental risk assessment rarely focused on exposures to multi-component mixtures which may cause toxicological interactions and usually ignored that toxicity is a process in time, which may underestimate the environment risk of mixtures.
This dose response was not adjusted for the counterveiling effect of MeHg and so may underestimate the true relationship or suggest a plateau in benefit that is in fact an indication of MeHg toxicity (see above).
That may underestimate the damage.
That forecast, however, may underestimate the increase.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com