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Exact(9)
TST may underestimate risk for infection with TB in children.
Thus, LDL cholesterol may underestimate risk in patients with the metabolic syndrome (2, 8).
Similarly, CURB-65 may underestimate risk in elderly patients with co-morbidities.
Conversely, the SCORE equation may underestimate risk in Russia and other Eastern European countries that are experiencing extremely high rates of CVD mortality [ 30, 31].
On the other hand, a model with a simple untransformed linear term for cumulative exposure may not fit the attenuating data as well and may underestimate risk in the low-dose region, resulting in excessively large estimates of EC01.
Age-specific population data used to calculate rates for immersion sites may underestimate risk of drowning; however, water exposure data 18 and pool data 42 were not available for Queensland.
Similar(51)
Conversely, a model of untransformed (linear) exposure may underestimate risks attributable to exposures in the low-dose region.
The common use of a single receptor end point to assess bioactivity upon transformation may therefore underestimate risk in cases where parents and products bind to different nuclear receptors.
Traditional tools to evaluate cardiovascular disease risk may underestimate the risk of cardiovascular events.
Moreover, because PAH toxicity is also linked to estrogenicity of the compounds, the PAH bioactivation potency of colon microbiota suggests that current risk assessment may underestimate the risk from ingested PAHs.
Therefore, risk estimates based on ambient measurements may over- or underestimate risk, leading to ineffective or inefficient management strategies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com