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Replication stress is a source of DNA damage, which may ultimately trigger activation of the p53-p21 pathway (Bartek and Lukas, 2001).
ER stress may act as a defense mechanism against external insults; however, prolonged and/or severe ER stress may ultimately trigger apoptosis.
Physical exercise may represent one possible way to counteract atrophy and fatigue in FSHD but its effects have not been fully investigated due to concerns that it may ultimately trigger disease progression.
Not only does this influx activate a number of intracellular signaling pathways, it is taken up by mitochondria causing mitochondrial swelling, impairment of respiration, increased production of reactive oxygen species and may ultimately trigger mitochondrial permeabilization (MP) and cell death [1], [5], [6] (Fig. 1).
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There are several candidates that may signal back from the stroma to ultimately trigger epithelial cell proliferation, foremost being insulin-like growth factor-1.
Attempting to do so will ultimately trigger a reflex that forces us to start breathing again.
This does not necessarily imply that they are listed as hazardous substances on the product SDS, as they may not have directly and ultimately triggered the classification of the mixture (see guidance on the application of the CLP criteria, [15]).
We can postulate that the impact may accelerate a pathological process already ongoing or precipitate a detrimental tissue response that ultimately triggers the disease in genetically susceptible individuals.
However, it may take further evidence to convince other scientists that it was a genetic innovation in a microscopic organism that ultimately triggered the biggest biological crisis in the history of life on earth.
Friction with America over relocating the marine base there ultimately triggered Mr Hatoyama's downfall.
The move ultimately triggered a precipitous drop in both stock price and shoppers.
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