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Although this might take years, such a strategy may ultimately identify molecular pathways for common human diseases, some of which might overlap, that are potential pharmacological targets.
Helminth infections and the use of helminth-derived products, such as ES-62, serve as valuable tools for dissecting key regulatory check-points balancing proinflammatory responses and resolution of pathogenic inflammation that may ultimately identify new clinically relevant therapeutic targets.
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Improved understanding of the cellular mechanisms involved in the effects of testosterone on the heart may reveal mechanisms involved in the increase in susceptibility to cardiovascular diseases in aging and may ultimately help identify new targets for intervention in the treatment of these diseases in both men and women.
Together with the determination of muscle mass and fibres composition, objective characterization of muscle function may ultimately help identifying specific deficits amendable with tailored rehabilitation programs and providing baseline and outcome measures.
Furthermore, use of experimental models of head injury to provoke neurodegeneration in genetically modified animals may ultimately serve to identify key components of the pathogenetic molecular cascades as well as susceptibility genes for a variety of neurodegenerative diseases.
Therefore, the application of SEN-guided MDR may ultimately help researchers identify and validate gene-gene and/or gene-environment interactions to serve as effective cancer prognostication tools.
These findings further support the hypothesis that MMP2 is important in Carcinogenesis and may ultimately help in identifying high-risk populations for NPC.
If this appears to be a canonical response, this may ultimately help in identifying signaling pathways underlying the organismal response to heat shock in particular or stress in general that lead to perturbations in recombination frequency.
Ultimately, identifying the genetics events leading to MDS initiation may provide insight into targeted therapy for MDS and AML.
Therefore, this approach may ultimately be useful to identify key regulatory elements and to complement other sequence-based genome annotation efforts, which will provide further insights into gene regulatory mechanisms in P. falciparum.
How are such functional associations ultimately identified?
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