However, we expect the real number of intact OR genes in the zebra finch to be larger, because many partial genes may turn into intact genes in the next assembly of the zebra finch genome.
Some genes may turn on, for example, because other genes that normally help kept them silent have shut off.
Many of the intact mitochondrial copies of these genes may turn out, upon further (especially cDNA) analysis, to instead be cryptic pseudogenes.
For example, epigenetic modifications, such as DNA methylation and histone modifications, may turn on and off genes in DNA independent of the structural changes.
Regardless, the higher structure complexity of the 5'-UTR in phzA1-G1, as compared with that of the phzA2-G2, suggesthattherethere are key switches located in this non-coding region which may turn on or off gene expression in response to environment cues and which determines the amount of PCA synthesis.
The CYT19 gene may turn on during a certain developmental stage and be more or less active at different ages in a way that depends on a person's DNA sequence.
These operators not only make the resulting iPGA more efficient (in terms of exploration as well as exploitation of various schemata) but also act as an insurance agent against the loss of certain genes, which may turn out to be useful in later stages of evolution as well as against premature convergence.
Screening in silico the high number of combinations of multiple gene deletions may turn out to be costly and practically impossible.
Characteristic tumor associated gene expressions may turn out to have desirable properties that can be used to enhance sensitivity at the expense of specificity.
The selected gene set may turn out to be a valuable reference set for identification and validation of biomarkers of OSCC.
