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For example, protein phosphorylation may trigger substrate degradation by proteolytic enzymes, direct intracellular protein sorting or drive the assembly/disassembly of active complexes in signaling, transcription, translation, cell division and organelle biogenesis.
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Interestingly, the human structure most closely resembles the inhibitor-bound structure, suggesting that binding of the phosphate moiety of the substrate may trigger this conformational change.
Alternatively, the different substrates may trigger the same series of conformational changes but with different kinetics.
In this way, the substrate loading on the periplasmic side may trigger the formation of the ATPase catalytic site in the cytosolic NBD dimer, and subsequently cause a COut-to-CIn conformational change (Fig. 1C).
The difference in the phosphorylation/dephosphorylation of substrates downstream of these two enzymes may trigger fast and slow gene transcription, respectively.
Alternatively, in the presence of a membrane potential, negatively charged substrates per se generate an outward force, which may trigger the CIn-to-COut conformational change of the exporter.
Chronic morphine addiction may trigger functional changes in the mesolimbic dopamine system, which is believed to be the neurobiological substrate of opiate addiction.
The additional oxygen atom may alter the stability of the substrate, leading to other molecular rearrangements (Coon et al. 1996; Bergé et al. 1998), or it may trigger conjugation by enzymes such as glutathione-S-transferases (reviewed in Tu and Akgül 2005).
Then the visits may trigger many subsequent hospitalizations and I.C.U.
Stressful life experiences may trigger the disease's initial onset.
"It may trigger 'What about my skin?' " he continued.
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