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In spite of this similarity, it has been shown that different environmental factors may trigger gene expression.
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Only mobile 24-nt sRNAs have been associated with RNA-dependent DNA methylation (RdDM) in recipient cells that may trigger transcriptional gene silencing (TGS) [ 63].
Certainly, cumulative damage may trigger state-specific genes.
It could be speculated that gene duplication of the A3 genes may trigger speciation, possibly through the differential fitness against viral infections that the additional A3 gene copy provides.
The difference in the phosphorylation/dephosphorylation of substrates downstream of these two enzymes may trigger fast and slow gene transcription, respectively.
Water stress may trigger different stress-responsive gene expression in different tissues at the same developmental stage or in the same tissue at different developmental stages.
Furthermore, although the global changes more, although the global changes in histone modifications appear to be transient, with the effect peaking at about 24 hours following initial ethanol exposure, it is likely that these changes may trigger secondary changes in gene expression (including those of miRNA) or DNA modification that are much longer lasting.
Early changes in collagen genes may trigger the accumulation of ECM components, promoting fibrosis in the later stages of diet-induced obesity.
This observation is consistent with results by Maxwell et al. [ 42], which indicate that reduced serum cholesterol levels may trigger expression of some genes involved in lipid metabolism.
There is increasing evidence that smoking is an environmental risk factor that, in the context of HLA-DR SE genes, may trigger RA-specific immune reactions to citrullinated proteins.
Thus, significant upregulation of a gene, followed by attainment of a high local concentration of the gene product, may trigger a humoral immune response against such a protein.
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