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Reductions in mitogenic signal intensity may normally cause cells to arrest and/or differentiate, whereas signal prolongation may trigger differentiation or death (Traverse et al, 1992; Dolmetsch et al, 1997).
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Taken together, these data suggest that long-term exposure to relaxin may trigger differentiation-promoting and anti-invasive changes in breast cancer cells.
Thus, the milieu of chronic myocardial inflammation may trigger their differentiation not just into adipocytes and myofibroblasts, but also possibly in cells capable of attracting and supporting lymphocytes.
In such cases, sdY may trigger testicular differentiation through a dosage mechanism, similarly to the dmrt1 gene dosage hypothesis in chicken (Smith et al. 2009).
MVs that are released from injured cells may deliver specific signals to stem cells that may trigger their differentiation and may represent a mechanism of physiological tissue repair [ 23].
The environment in the BS being more favorable for harboring the transplanted cells could explain this and that site-specific cues in the BS may trigger migration, differentiation, and sprouting of these cells.
Levels of Jagged-1 and Notch increased during the differentiation process, and may trigger keratinocyte terminal differentiation and cornification [24].
We conclude that MAPK signaling levels set the GATA4-mCherry threshold dose required to trigger differentiation.
Therefore, the early expression of VGCC subunits may be required for normal pancreatic β-cell development and in combination with other signals may trigger the further differentiation of endocrine and β-cell lineages.
Because KO keratinocytes showed growth arrest delay, PKC η may trigger keratinocyte terminal differentiation.
Besides, previous studies have shown that the application of mechanical loading on cultured mesenchymal stem cells (MSCs) may trigger their osteogenic differentiation with or without the addition of growth factors [ 8– 10].
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