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Collectively, the aberrant enrichment of HAT and HDAC activities may trigger carcinogenesis processes (Mottet and Castronovo et al. 2008).
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We hypothesized that this mechanism includes specific signal transduction pathways, which trigger carcinogenesis in normal cells, and promote or co-promote malignant transformation of cells.
Among those, STAT3 activation seems crucial to trigger carcinogenesis.
To test our hypothesis that dysregulation of innate immune responses acts to trigger carcinogenesis, we studied the expression of TLR2 and 4 in sporadic human colorectal cancer tissue.
Recent studies suggest that the deregulation of pathways, rather than individual genes, may be critical in triggering carcinogenesis.
Next, we hypothesized that "Darwinian-like" interactions between impaired and newly formed tissues may trigger cell death, since negative selection can drive elimination of less fit cells during development or carcinogenesis [ 1 11].
The changes may trigger some pushback.
Such events may trigger new PuLSaR recommendations.
Alternatively, insomnia may trigger TTH [32].
Everything may trigger you.
Certain pesticides may trigger autism.
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