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We chose to analyse the STin 2 polymorphism because it seems to influence the gene transcription in an allele-dependent manner and may thus modify neuronal transmission.

Interferon-γ may, thus, modify the cellular composition of the healing tissue and promotes wound contraction, attenuating adverse remodelling.

Furthermore, GSH is an antioxidative agent, and polymorphisms in GCLC, GCLM and GSTP1 may thus modify the MeHg-induced oxidative damage.

Disruption of the balance between MMPs and TIMPs may influence invasion and metastasis of cancer and may thus modify patient outcome [ 1].

In addition, although individuals with decreased kidney function are more commonly BP salt-sensitive, and kidney function may thus modify the association between dietary salt intake and microvascular complications, we found no evidence to support this contention.

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DNA methylation patterns may thus be modified by altered expression or activity of epigenetic regulators such as TET.

Potassium has been shown to exert an inhibitory effect on sodium sensitivity [ 13], and the association between sodium intake and microvascular complications may thus be modified by potassium intake.

This mutation may affect one of these fusion steps and thus modify the fusion activity of S protein and syncytia formation.

Corticosteroids present anti-inflammatory properties that may reduce the intense proinflammatory cytokine response and thus modify the occurrence and severity of organ failures [ 3].

Hypothesis (2) is compatible with recent mass spectrometry data and implies that the charge of several amino acid side chains may have been altered, thus modifying substantially the permeation properties of the channels in living cells.

Changes in these other, related genes may thus reduce or modify the effect of CLOCK and ADCYAP1 on migratory behavior, and explain the pattern of relationships identified in both previous studies (described above) and this work.

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