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The structures reveal the molecular basis for isoform specificity of the DARPins and their ability to prevent JNK activation and may thus form the basis of further investigation of the JNK family as well as novel approaches to drug design.
Interest in the pervasiveness of interpretation in legal reasoning, and in the Janus-faced nature of interpretation may thus form part of the background which has led legal theorists like Dworkin to deny that the distinction between identifying existing law, and developing and changing the law, as understood by certain legal positivists, is a tenable or coherent one.
As quail are able to discriminate familiar from unknown conspecifics [42], [73], we assume that, in a reproductive area, all quail know one another and may thus form a "stable group".
Sectm1 Ig-like domain may thus form an atypical disulfide bridge while maintaining the Ig-fold.
The union of our two MSpresso-predicted datasets (LCQ, ORBI) and the protein reference datasets comprises 3797 cytosolic proteins expressed in yeast growing in rich medium at log-phase; 2364 (62%) of these proteins occur in two or more datasets, and may thus form a core set of reliably identified proteins.
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These deficits may further interact and thus form a multi-causal basis for the patients' problems in every-day life which need to be considered when planning individually targeted intervention in PPA.
Storm waves may drive forward coral fragments derived from staghorn corals growing on the windward slopes of the reef, forming shingle banks; successive superposed banks may thus be formed.
(iii) Partly depending on whether the adjacent sedimentary basins were over- or underfilled, some erosion surfaces may have been controlled by raised base levels and may thus have formed at high elevations; however, in many cases they were disconnected from marine base levels by rapid surface uplift, thus acquiring their elevated positions in recent time.
Radicals are produced by indirect reduction of a compound which cleaves to a good hydrogen atom acceptor; this acceptor abstracts a hydrogen atom from a donor, and the radical thus formed may couple with the mediator or react in other ways.
If Phobos breaks apart 40 million years from now, the ring thus formed may last only a million years, the researchers estimate.
If the sparse aggregated channel matrix H ˜ is invertible, then the BF matrix W ˜ thus formed may not have zeros at places where needed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com