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Exclusion of low-quality trials may thus directly impact our clinical practise.
Pulmonary infection may thus directly induce tumor progression in NSCLC.
TAMs may thus directly contribute to the bone resorption associated with skeletal metastasis.
Apo-ER may thus directly regulate the RARα gene to maintain the basal expression level of RARα1.
Rbf1 may thus directly affect output of these essential growth-control and differentiation pathways by regulation of expression of receptors, kinases and downstream effectors.
Oxylipins may thus directly or indirectly contribute to the restriction of pathogen ingress in local or systemic defense reactions such as SAR.
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AioR may thus interact, directly or indirectly, with components of the flagellar cascade.
Fat accumulation in fetal liver may thus originate directly from maternal lipid transfer and represents a "very first hit" of lipotoxicity during early life development.
The position of Pro on the surface of GKRP and its close vicinity to Asp [ 47] and Gln [ 49], which appear to form a salt bridge with Arg of GK, is almost certainly of functional significance, and the P446L substitution may thus interfere directly with binding to GK (compare with Figure 1D).
In this respect, it is interesting that Fecalibacterium prausnitzii, a commensal strain poorly represented in the microbiota of patients with Crohn's disease, can produce soluble anti-inflammatory factors which may thus be delivered directly to the adjacent mucosa [23].
Miscall frequency may thus also be directly linked to the observed bias in sequence coverage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com