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GSK3β may therefore regulate HDAC6 activity by phosphorylation.
GABAA receptor modulation may therefore regulate segmental and peripheral components of nociception.
This is an interesting observation as cdx4 is upstream and may therefore regulate HOXB4, reducing its negative impact on lymphopoiesis.
In kinases, the activation loop also forms part of the peptide substrate binding pocket [45], [46] and it may, therefore, regulate substrate binding.
Nuclear FGF3 may therefore regulate ribosomal biogenesis.
Tsc2 may therefore regulate ubiquitinations on Lys41 Lys85 in Cat1.
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Chromatin immunoprecipitation and promoter mutational analyses showed that β-catenin/LEF (lymphoid enhancer binding factor)/TCF1 (T-cell factor 1) occupy a cognate binding site in the proximal runx2 promoter and may therefore directly regulate runx2 expression [ 50].
Furthermore, PPP1 may additionally dephosphorylate TCTEX1D4 itself, and therefore regulate its function.
Microtubule-dependent intracellular trafficking may therefore be regulated by modulating the activity of HDAC6.
Mitf functions in diverse cell types and may therefore be regulated by different miRNAs in the different tissues.
This group of genes showed more modest changes in gene induction or repression (circa 1.5 to 2-fold difference) and may therefore be regulated by different mechanisms.
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