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Background: Xenobiotic metabolizing enzymes (XMEs) are important detoxifiers of hazardous environmental agents, and their polymorphisms may therefore modify the risk of environmentally induced cancers.
Mammalian herbivores can have dramatic effects on the vegetation through different mechanisms, and may therefore modify resource distribution or create habitat for other species.
Variations in creatinine clearance may therefore modify FeUrea.
150 Lead toxicokinetics and bone metabolism may therefore modify the lead-ALS association.
Their presence may therefore modify gene neighbourhood in a non-random, non-selective manner.
Variants in the TP53 gene may therefore modify the risk of late skin toxicity after radiotherapy.
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Modifying substrates and diet may therefore change the balance of oxylipins and may be responsible for the purported benefits of these lifestyle modifications.
Changes in NO availability may therefore theoretically modify superoxide and peroxynitrite activities in tissues, but published data are contradictory regarding aging effects on muscle NO availability.
Similarly, parathyroid hormone stimulates the kidneys to produce 1,25(OH)2D [ 1] and may therefore also modify the association between vitamin D and vascular complications.
Because homozygous deletions in GSTM1 have been associated with changes in arsenic methylation capability [ 22], GSTM1 genotype may alter arsenic toxicity and therefore modify the association between arsenic and urinary 8-OHdG.
This is because the poor may be too poor to even afford falling ill and therefore modify their perception of illness so as to avoid incurring payments [ 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com