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Complete and sustained HER3 and/or HRG inhibition may, therefore, inhibit HER3-dependent resistance to EGFR inhibition and produce a more complete blockade of signaling from HER family members (Xia et al., 2005, Sergina et al., 2007).
The serum autoantibodies to ACE2 may therefore inhibit ACE2 activity, and the inhibition may be reversible after immunosuppressive therapy, based on the data from Patient 1.
A key mechanism of action of therapeutic hypothermia is the inhibition of the pro-inflammatory cascade 51; and hypothermia may therefore inhibit both protective and damaging responses.
NSC11668 may therefore inhibit its own cellular export, potentiating any pharmacological effect.
The high Mn concentrations in AMD may therefore, inhibit adsorption of Cu to maghemite NPs at low pH.
2ME2 may therefore inhibit osteoclast formation and activity indirectly by blocking HIF-1α activity and VEGF secretion by osteoblasts.
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Targeting this site may therefore not inhibit the enzyme, although the possibility of long range conformational changes induced by the binding of a drug cannot be ruled out.
The lack of let-7e may release NGF deprivation and therefore inhibit apoptosis, leading to tumor aggression and HCC metastasis.
Therefore, inhibiting the UPP may be an effective approach to treat MM (Landis-Piwowar, 2012).
Therefore, inhibiting Axl function may represent a potential target for future antiviral therapies.
Therefore, inhibiting LAT1 function may provide a new and effective therapeutic target of oesophageal cancer.
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