Together, these findings argue a novel function of Capn4 in invasion and metastasis of NPC, and thereby suggest that Capn4 may represent an independent prognostic factor and a potential therapeutic target in NPC.
As a result, fewer molecules may be ionized, thereby suggesting lower levels locally than are actually present.
Recently, Diamandis et al (2000d) have shown that hK6 is elevated in the cerebrospinal fluid and blood of individuals with histologically confirmed Alzheimer's, thereby suggesting hK6 may be of value in the diagnosis of this disorder.
Fundus examination in a patient with vitreous hemorrhage secondary to Eales' disease often shows a combination of both fresh and old vitreous hemorrhage at any time the patient is examined, thereby suggesting that there may be bleeding on more than one occasion in these patients.
Network and pathway analyses have also shown that various signaling pathways can interact or even partially overlap with each other, thereby suggesting that IPF may be the result of multiple, consecutive (or interactive) biological events, possibly triggered by environmental stimuli.
But the latter showed increasing hospitalization rates over time thereby suggesting that PCPs may be able to predict future deterioration in patients with relatively good current health status.
Long-term use of ARBs is associated with a lower incidence of cancer occurrence, thereby suggesting that ARBs may prevent cancer development.
However, 10 events showed distinct occurrence in the cultivated or wild soybeans (Supplementary Table S11), thereby suggesting that they may be candidate domestication genes.
It should be noted that our 12-month-old PS1-KI mice did not show signs of age-related cognitive decline, thereby suggesting that exenatide may act as cognitive enhancer on mice that still have a valid cognitive reserve.
It has been described that human Tregs express CD39, an ectonucleotidase involved in adenosine triphosphate (ATP) breakdown and the production of immunosuppressive adenosine, thereby suggesting that CD39 may be a functional marker on Tregs [ 27, 28].
