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Pharmacologic modulation of Nav channels may thereby represent a viable therapeutic approach for the treatment of many neurological disorders such as epilepsy, arrhythmia, and pain.

Neutralisation of the IL-33/ST2 axis may thereby represent an effective therapeutic target in inflammatory bowel disease.

Possibly, the requirement of the two extra components MRPP1 and MRPP2 may thereby represent an adaptation to the non-canonical structures of animal mitochondrial tRNAs.

The volume decrease may thereby represent a trait-dependent vulnerability of the patients to depression, taking place before recurrence of the disease.

The genes SALL4 and TM4SF5 were expressed to a higher extent in the tumours from deceased patients in our material and have been reported to be up-regulated in other cancers, and may thereby represent putative oncogenes [ 41, 42].

Besides being biomarkers that predict outcome in patients with acute lung injury, their activation of inflammation and coagulation seems also to play a pivotal role in the pathogenesis of acute lung injury, and may thereby represent an interesting novel target for therapeutic intervention.

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The forcing function represents a number of apparently random events (e.g. formation of bubbles at the air-distributor, bubble eruptions at the surface of the bed) and may thereby be approximated as white noise.

Drinking water may thereby be contaminated with pathogenic Y. enterocolitica.

Another limitation is the results cannot be translated directly to all MOH patients as our patients are included from tertiary centres, and thereby represent selected patients that may have failed prior treatment programmes within first or second line.

Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets.

Genes with distinct functions in physiological angiogenesis are often deregulated in pathologies such as cancer and may play pivotal roles, thereby representing new therapeutic targets [35].

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