Sentence examples for may target several from inspiring English sources

Computational and experimental approaches indicate that a single miRNA may target several dozen or even hundreds of mRNA [ 4].

Here we concentrate on an alternative approach, the Stacking Binding Matrix (SBM), in which we can incorporate all of the known targets for a given miRNA (in general a miRNA may target several sites) into a search for additional targets.

It is challenging to determine the scope of miRNA regulation in a biological process as each miRNA may target several mRNAs and each mRNA may be regulated by multiple miRNAs [ 46].

As is the case for eukaryotic microRNAs, bacterial sRNAs may target several mRNAs [ 10], and mRNAs may be regulated by one or more sRNAs [ 11], forming complex interdependent regulation networks.

These results might also be explained by the acknowledged 'promiscuity' of miRNAs, as a single miRNA may target several different gene transcripts in a time- and model-dependent manner [ 10, 30].

Finally, miR-15a may target several members of the NF-κB pathway and reduced circulating miR-15a could functionally augment NF-κB signaling leading to increased inflammatory cytokine production and increased endothelial injury.

Further experimental studies are needed to confirm this, but if true, this would be an example of how miRNAs may effectively target several genes in the same pathway.

Every tumor has five to ten flawed genes driving its growth, and researchers may have to target several simultaneously with cocktails of drugs, the approach that worked against AIDS.

However, the mechanisms of tissue injury are complex and effective neuroprotective therapy may have to target several different mechanisms in parallel.

Drug delivery system for melanoma therapy may target the several pathways involved in melanoma development such as three-tiered Ras/Raf/MEK mitogen-activated protein kinase (MAPK); PI(3 K; NF-kappaB; p16INK4a/RB and ARF signalling pathways.

Thus, flavonols may serve as drug leads for designing compounds that target several cyclic amidohydrolases.