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In this study, we designed and executed an approach to prioritize drugs that may target multiple age related disorders.
Individual miRNAs may target multiple mRNAs.
The "combinatorial circuitry model", predicts that a single miRNA may target multiple mRNAs.
These losses are often broad, and may target multiple loci, reducing the function of more than one gene.
A single sRNA may target multiple mRNAs and typically binds to short complementary regions overlapping the ribosome-binding site and/or start codon.
In the cell periphery, ERK activity may target multiple substrates in the synaptic and dendritic compartment, and therefore contribute to the initial steps that lead to long-term synaptic changes [4] [6].
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Theoretically, multiple active phytochemical components in the TCM formulae may simultaneously target multiple molecules/pathways and thus potentially achieve superior effect as compared to single compounds alone [3].
According to the hypothesis of TCM, multiple active phytochemical components in the TCM formulae may simultaneously target multiple molecules/pathways, and thus potentially achieve superior effect to single compound.
We hypothesized that, since alkaloids and flavonoids have substantially different biochemical characteristics, a combinational approach may simultaneously target multiple molecular and cellular pathways involved in the process of GBM carcinogenesis.
An effective malaria vaccine may need to target multiple parasite antigens from different stages of the life cycle.
For these reasons, therapeutic interference with PI3K signalling in cancer may have to target multiple PI3K isoforms, possibly simultaneously.
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